On April 21, 2006, the first-ever full-length feature film created entirely with CGI, 'Final Fantasy: The Spirits Within', was screened at the Cannes Film Festival.

On April 21, 1998, the first-ever successful cloning of a human cell was announced by researchers at Advanced Cell Technology in Massachusetts.

On April 21, 1969, the first-ever human-made object, the Soviet spacecraft Soyuz 7K-OK, was launched into Earth's orbit.